Formulating Poorly Water Soluble Drugs
Robert O. Williams III, Daniel A. Davis Jr., Dave A. Miller
The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
카테고리:
년:
2021
판:
3
출판사:
Springer
언어:
english
페이지:
855
ISBN 10:
1461411432
ISBN 13:
9781461411437
시리즈:
978-3030887186
파일:
EPUB, 79.42 MB
IPFS:
,
english, 2021